Allopregnanolone is a neurosteroid produced through the metabolization of progesterone which occurs in both male and female brains. It has a calming effect, and its synthetic form is commonly prescribed as an antidepressant.

The amygdala is located in the temporal lobe, and it is part of the limbic system, involved in emotional and behavioral responses necessary for survival. It is believed to contribute to fear, anxiety, aggression, learning, caregiving, memory, and addiction. 

Androstenedione is an anabolic steroid produced in the testes, ovaries, and adrenal glands and converted into sex hormones, such as estrogen and testosterone. Synthetic androstenedione is used as a steroid for muscle growth and athletic performance, as well as for erectile dysfunction and fatigue; however, medical professionals have found significant risks with such applications.